Selected Publications

  • Winans, S., Yu, H. J., de los Santos, K., Wang, G.Z., KewalRamani, V.N. and Goff, S.P. (2022) A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeats. Nature Commun. 13: 1474.

  • Geis, F.K., Sabo, Y., Chen, X., Li, Y., Lu, C. and Goff, S.P. (2022) CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection. Proc. Natl. Acad. Sci. U.S.A. 119: e2116735119.

  • Wang, G.Z. and Goff, S.P. (2021) Moloney murine leukemia virus p12 is required for histone loading onto retroviral DNAs. J. Virol. 95: e0049521.

  • Winans, S. and Goff, S.P. (2020) Mutations altering acetylated residues in the CTD of HIV-1 integrase cause defects in proviral transcription at early times after integration of viral DNA. PLoS Pathog. 16: e1009147.

  • Wang, G.Z. and Goff, S.P. (2020) Yin Yang 1 is a potent activator of human T lymphotropic virus type 1 LTR-driven gene expression via RNA binding. Proc. Natl. Acad. Sci. U.S.A. 117: 18701-18710.

  • Sabo, Y., de Los Santos, K. and Goff, S.P. (2020) IQGAP1 negatively regulates HIV-1 Gag trafficking and virion production. Cell Rep. 30: 4065-4081.e4.

  • Geis, F.K. and Goff, S.P. (2019) Unintegrated HIV-1 DNAs are loaded with core and linker histones and transcriptionally silenced. Proc. Natl. Acad. Sci. U.S.A. 116: 23735-23742.

  • Zhu, Y., Wang, G.Z., Cingoz, O. and Goff, S.P. (2018) NP220 mediates silencing of unintegrated retroviral DNA. Nature 564:278-282.

  • Metzger, M.J., Paynter, A.N., Siddall, M.E. and Goff, S.P. (2018) Horizontal transfer of retrotransposons between bivalves and other aquatic species of multiple phyla. Proc. Natl. Acad. Sci. U.S.A. 115:E4227-E4235.

  • Cingoz, O. and Goff, S.P. (2018) Cyclin-dependent kinase activity is required for type I interferon production. Proc. Natl. Acad. Sci. U.S.A. 115:E2950-E2959.

  • Lee, A., Cingoz, O., Sabo, Y. and Goff, S.P. (2018) Characterization of interaction between Trim28 and YY1 in silencing proviral DNA of Moloney murine leukemia virus. Virology 516:165-175.

  • Wang, C. and Goff, S.P. (2017) Differential control of retrovirus silencing in embryonic cells by proteasomal regulation of the ZFP809 retroviral repressor. Proc. Natl. Acad. Sci. U.S.A. 114:E922-E930.

  • Metzger, M.J., Villalba, A., Carballal, M.J., Iglesias, D., Sherry, J., Reinisch, C., Muttray, A.F., Baldwin, S.A. and Goff, S.P. (2016) Widespread transmission of independent cancer lineages within multiple bivalve species. Nature 534: 705-709.

  • Griffin, D.O. and Goff, S.P. (2015) HIV-1 is restricted prior to integration of viral DNA in primary cord-derived human CD34+ cells. J. Virol. 89: 8096-8100.

  • Metzger, MJ., Reinisch, C., Sherry, J., and Goff, S.P. (2015) Horizontal transmission of clonal cancer cells causes leukemia in soft-shell clams. Cell 161: 255-263.

  • Kao, T.-H., Liao, H.-F., Wolf, D., Tai, K.-Y., Chuang, C.-Y., Lee, H.-S., Kuo, H.-C., Hata, K., Zhang, X., Cheng, X., Goff, S.P., Ooi, S.K., Bestor, T.H. and Lin, S.-P. (2014) Ectopic DNMT3L triggers assembly of a repressive complex for retroviral silencing in somatic cells. J. Virol. 88: 10680–10695.

  • Arriagada, G., Metzger, M.J., Muttray, A., Sherry, J., Reinisch, C., Street, C., Lipkin, W.I., and Goff, S.P. (2014) Activation of transcription and retrotransposition of a novel retroelement, Steamer, in neoplastic hemocytes of the mollusk Mya arenaria. Proc. Natl. Acad. Sci. U.S.A. 111: 14175-14180.

  • Schlesinger, S., Meshorer, E. and Goff, S.P. (2014) Asynchronous transcriptional silencing of individual retroviral genomes in embryonic cells. Retrovirology 11: e31.

  • Wang, G.Z., Wolf, D. and Goff, S.P. (2013) EBP1, a novel host factor involved in Primer Binding Site (PBS)-dependent restriction of Moloney murine leukemia virus in embryonic cells. J. Virol. 88: 1825-1829.

  • Goff, S.P. (2013) HIV: Slipping under the radar. Nature News and Views 503: 352-353.

  • Sabo, Y., Walsh, D., Barry, D.S., Tinaztepe, S., de los Santos, K., Goff, S.P., Gundersen, G.G. and Naghavi, M.H. (2013) HIV-1 induces the formation of stable microtubules to enhance early infection. Cell Host Microbe 14: 535-546.

  • Schlesinger, S., Lee, A., Wang, G.Z., Green, L. and Goff, S.P. (2013) Proviral silencing in embryonic cells is regulated by Yin Yang 1. Cell Rep. 4: 1-9.

  • Lukic, Z., Goff, S.P., Campbell, E.M. and Arriagada, G. (2013) Role of SUMO-1 and SUMO interacting motifs in rhesus TRIM5a-mediated restriction. Retrovirology 10: e10.

  • Beyer, A.R., Bann, D.V., Rice, B., Pultz, I.S., Kane, M., Goff, S.P., Golovkina, T.V. and Parent, L.J. (2013) Nucleolar trafficking of the mouse mammary tumor virus Gag protein induced by interaction with ribosomal protein L9. J. Virol. 87: 1069-1082.

  • Schlesinger, S. and Goff, S.P. (2013) Silencing of proviruses in embryonic cells: Efficiency, stability, and chromatin modifications. EMBO Rep. 14: 73-79.

  • Green, L., Houck-Loomis, B., Yueh, A. and Goff, S.P. (2012) Large ribosomal protein 4 increases efficiency of viral recoding sequences. J Virol. 86: 8949-8958.

  • Goff, S.P. (2012) Retroviridae: The Retroviruses and their Replication. In Fields Virology, sixth edition (Knipe, D. and Howley, P., eds.), Lippincott Williams & Wilkins, Philadelphia PA, Chapter 47, 1424-1473.

  • Arriagada, G., Muntean, L.N. and Goff, S.P. (2011) SUMO-interacting motifs of human TRIM5alpha are important for antiviral activity. PLoS Pathog. 7: e1002019.

  • Hogg, J.R. and Goff, S.P. (2010) Upf1 senses 3' UTR length to potentiate mRNA decay. Cell 143: 379-389.

  • Qiu, Z.Z., Cang, Y. and Goff S.P. (2010) c-Abl tyrosine kinase regulates cardiac growth and development. Proc. Natl. Acad. Sci. U.S.A. 107: 1136-1141.

  • Valente, S.T., Gilmartin, G.M., Venkataraman, K. and Goff, S.P. (2009) HIV-1 mRNA 3' end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8. Mol. Cell 36: 279-289.

  • Wolf, D. and Goff, S.P. Embryonic stem cells use ZFP809 to silence retroviral DNAs. (2009) Nature 458: 1201-1204.

  • Valente, S.T., Gilmartin, G.M., Mott, C., Falkard, B. and Goff S.P. (2009) Inhibition of HIV-1 replication by eIF3f. Proc. Natl. Acad. Sci. U.S.A. 106: 4071-4078.

  • Wolf, D., Hug, K. and Goff S.P. (2008) TRIM28 mediates primer binding site-targeted silencing of Lys1,2 tRNA-utilizing retroviruses in embryonic cells. Proc. Natl. Acad. Sci. U.S.A. 105: 12521-12526. 

  • Wolf, D. and Goff, S.P. (2007) TRIM28 mediates primer binding site-targeted silencing of murine leukemia virus in embryonic cells. Cell 131: 46-57.

  • Cang, Y., Zhang, J., Nicholas, S.A., Kim, A.L., Zhou, P. and Goff, S.P. (2007) DDB1 is essential for genomic stability in developing epidermis. Proc. Natl. Acad. Sci. U.S.A. 104: 2733-2737. 

  • Cang, Y., Zhang, J., Nicholas, S.A., Bastien, J., Li, B., Zhou, P. and Goff, S.P. (2006) Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells. Cell 127: 929-940.

  • Naghavi, M.H., Hatziioannou, T., Gao, G. and Goff S.P. (2005) Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells. Genes Dev. 19: 1105-1115.

  • Evans, M.J., Rice, C.M. and Goff, S.P. (2004) Phosphorylation of Hepatitis C virus NS5A modulates its protein interactions and viral RNA replication. Proc. Natl. Acad. Sci. U.S.A. 101: 13038-13043.

  • Orlova, M., Yueh, A., Leung, J. and Goff, S.P. (2003) Reverse transcriptase of Moloney murine leukemia virus binds to eukaryotic release factor 1 to modulate suppression of translational termination. Cell 115: 319-331.

  • Gao, G., Guo, X. and Goff, S.P. (2002) Inhibition of retroviral RNA production by ZAP, a novel CCCH-type zinc finger protein. Science 297: 1703-1706. 

  • Tachedjian, G., Orlova, M., Sarafianos, S., Arnold, E. and Goff, S.P. (2001) Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type1 reverse transcriptase. Proc. Natl. Acad. Sci. U.S.A. 98: 7188-7193.

  • Li, B., Boast, S., de los Santos, K., Schieren, I., Quiroz, M., Teitelbaum, S.L., Tondravi, M.M. and Goff, S.P. (2000) Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation. Nat. Genet. 24: 304-308.

  • Yuan, B., Li, X. and Goff, S.P. (1999) Mutations altering the Moloney murine leukemia virus p12 Gag protein affect virion production and early events of the virus life cycle. EMBO J. 18: 4700-4710.