R01 CA 030488-42 - Goff

Mechanisms of Silencing of Retroviral DNAs in Embryonic Cell Lines

The goal of this project is to expand our understanding of the Moloney murine leukemia virus – prototype of the simple mammalian retroviruses, and a model for the human retroviruses HTLV-1 and HIV-1 – and of the host regulation of viral DNA expression.

PI, 1/1/20 to 1/1/24

5R01 AI162694-03 - subcontract Goff

Defining the nuclear import pathways of HIV-1

This application aims to define and visualize the specific nuclear pore constituents that interact and mediate the nuclear import of HIV-1 and how specific NPC usage affects viral integration in target cells. Collectively this application would close critical gaps to our understanding in to the nuclear import of HIV-1.

Subaward, 7/21 to 6/25

U54 AI170660-02 - subcontract Goff

Center for Structural Biology of HIV RN

The goal of this project is to develop virtual and experimental screens for broadly targeting RNA regulatory elements in the HIV-1 genome.

Subaward, 6/22 to 3/27

U19 AI171401-01 - Goff

Metropolitan AntiViral Drug Accelerator (MAVDA)

Establish a dynamic antiviral drug discovery enterprise consisting of diverse projects developed by leading laboratories from academia and biopharma with robust drug discovery programs and strong track records of discovering novel active compounds against viruses of pandemic potential to develop Hits, Leads, Optimized Leads and Preclinical Development Candidates. Collectively, this Accelerator will function as central platform for academic-industry antiviral drug discovery. 

Core PI, 5/22 to 4/25

Simons Foundation Junior Fellowship

Fellowship Support for Benem-Orom Davids

Regulation and functions of the Arc gene product, a retroviral Gag protein.

PI, 7/21 to 6/24