Department of Microbiology & Immunology

Columbia University in the City of New York
Sagi Shapira, Ph.D.
Assistant Professor of Systems Biology and Microbiology & Immunology
Ph.D., University of Pennsylvania

Using systems biology approaches to decipher host-pathogen interactions

Our focus is to decipher the genetic and molecular circuitry that is at the interface of host-pathogen interactions. We would like to understand how this circuitry controls cellular responses to infection, imparts selective pressure on viruses and affects disease progression. Using animal models of infectious disease, molecular biology, and genomic and computational methods, we seek to generate mechanistic models of the dynamic interactions between host and pathogen. The efforts are aimed at developing general strategies for the study of host-pathogen dynamics. A mechanistic understanding of these relationships provides important insights into cellular machinery that control basic cell biology and have broad implications in human translational immunology and infectious disease research

Selected Publications

  1. Abe, T., Lee, A., Sitharam, R., Kesner, J., Rabadan, R. and Shapira, S.D. (2017) Germ-cell-specific inflammasome component NLRP14 negatively regulates cytosolic nucleic acid sensing to promote fertilization. Immunity 46: 621-634.
  2. Stockman, V.B., Ghamsari, L., Lasso, G., Honig, B., Shapira, S.D. and Wang, H.H. (2016) A High-throughput strategy for dissecting mammalian genetic interactions. PLoS One 11: e0167617.
  3. Tripathi, S., Pohl, M.O., Zhou, Y., Rodriguez-Frandsen, A., Wang, G., Stein, D.A., Moulton, H.M., DeJesus, P., Che, J., Mulder, L.C., Yanguez, E., Andenmatten, D., Pache, L., Manicassamy, B., Albrecht, R.A., Gonzalez, M.G., Nguyen, Q., Brass, A., Elledge, S., White, M., Shapira, S., Hacohen, N., Karlas, A., Meyer, T.F., Shales, M., Gatorano, A., Johnson, J.R., Jang, G., Johnson, T., Verschueren, E., Sanders, D., Krogan, N., Shaw, M., Konig, R., Stertz, S., Garcia-Sastre, A. and Chanda, S.K. (2015) Meta- and orthogonal integration of influenza "OMICs" data defines a role for UBR4 in virus budding. Cell Host Microbe 18: 723-735.
  4. Gupta P.B., Fillmore C.M., Jiang G., Shapira S.D., Tao K., Kuperwasser C. and Lander E.S. (2011) Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146: 633-644.
  5. Shapira S.D. and Hacohen N. (2010) Systems biology approaches to dissect mammalian innate immunity. Current Opinion in Immunology 23: 1-7.
  6. Shapira S.D., Gat-Viks I., Shum B.O.V., Dricot D., DeGrace M., Gupta P.B., Hao T., Silver S.J., Root D.E., Hill D.E., Regev A. and Hacohen N. (2009) A physical and regulatory map of host-influenza interactions reveals new critical pathways in influenza infection. Cell 139: 1255-1267.
  7. Shapira S., Harb O., Han J., Margarit J., Matrajt M., May M., Hoffman A., Freedman B., Roos D. and Hunter C.A. (2005) Initiation and termination of NF-kB signaling by the intracellular protozoan parasite Toxoplasma gondii. J. Cell Sci. 118: 3501-3508.
  8. Shapira S., Harb O., Cammano J. and Hunter C.A. (2004) The NF-kB signaling pathway: immune evasion and immunoregulation during toxoplasmosis. Int. J. Parasitology 34: 393-400. Invited Review
  9. Artis D., Shapira S., Mason N., Speirs K.M., Goldschmidt M., Caamano J., Liou H.C., Hunter C.A. and Scott P. (2002) Differential requirement for NF-kB family members in control of helminth infection and intestinal inflammation. J. Immunol. 169: 4481-4487.

Assistant Professor Sagi Shapira
Phone: 212-851-4674
Lab Phone: 212-851-4674
Fax: 212-305-1468

Department of Microbiology & Immunology, Columbia University + 701 W. 168 St., HHSC 1208 New York, NY 10032 Tel. 212-305-3647